Category Ergothioneine

Uptake and protective effects of ergothioneine in human endothelial… – PubMed – NCBI

Ergothioneine is a thiourea derivative of histidine found in food, especially mushrooms. Experiments in cell-free systems and chemical assays identified this compound as a powerful antioxidant. Experiments were designed to test the ability of endothelial cells to take up ergothioneine and hence benefit from protection against oxidative stress. Reverse-transcription polymerase chain reaction and Western blotting […]

Ergothioneine – Truth In Aging

Whilst reading a book called The New Science of Perfect Skin, I came across a new ingredient: ergothioneine. According to the books author, Daniel Yarosh PHD, ergothioneine is one of the few antioxidants along with vitamins, A, C and E with any strong evidence behind it to suggest that it works. I was intrigued.Ergothioneine is […]

Paramount levels of ergothioneine transporter SLC22A4 mRNA in boar seminal vesicles and cross-species analysis of ergothioneine and glutathione in seminal plasma.

Paramount levels of ergothioneine transporter SLC22A4 mRNA in boar seminal vesicles and cross-species analysis of ergothioneine and glutathione in seminal plasma.AuthorsNikodemus D, Lazic D, Bach M, et al. SourceJ Physiol Pharmacol 2011 Aug; 624 :411-9.AbstractErgothioneine ET is a unique natural antioxidant which mammalia acquire exclusively from their food. Recently, we have discovered an ET transporter ETT; gene […]

Discovery of the ergothioneine transporter.

Discovery of the ergothioneine transporter.AuthorsGründemann D, Harlfinger S, Golz S, et al. SourceProc Natl Acad Sci U S A 2005 Apr 5; 10214 :5256-61.AbstractVariants of the SLC22A4 gene are associated with susceptibility to rheumatoid arthritis and Crohns disease. SLC22A4 codes for an integral membrane protein, OCTN1, that has been presumed to carry organic cations like tetraethylammonium across the […]

The ergothioneine transporter controls and indicates ergothioneine activity–a review.

The ergothioneine transporter controls and indicates ergothioneine activity–a review.AuthorsGründemann D SourcePrev Med 2012 May.:S71-4.AbstractErgothioneine ET is a natural compound which humans and other vertebrates cannot synthesize themselves; it must be absorbed from food in which it is distributed very unevenly. In general, ET is considered an intracellular antioxidant. However, the precise physiological purpose of ET and the […]

Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system.

Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system.AuthorsMarkova NG, Karaman-Jurukovska N, Dong KK, et al. SourceFree Radic Biol Med 2009 Apr 15; 468 :1168-76.AbstractThe cellular defense system against harmful levels of reactive oxygen species consists of antioxidant enzymatic activities and small nonenzymatic molecules. L-ergothioneine has long been recognized […]

Harriet Lane Handbook: L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts.

L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts.AuthorsObayashi K, Kurihara K, Okano Y, et al. SourceJ Cosmet Sci 2005 Jan-Feb; 561 :17-27.AbstractErgothioneine EGT is a sulfur-containing amino acid, and is presumed to function as a natural antioxidant. The purpose of this study was to identify the nature […]

L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts.

L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts.AuthorsObayashi K, Kurihara K, Okano Y, et al. SourceJ Cosmet Sci 2005 Jan-Feb; 561 :17-27.AbstractErgothioneine EGT is a sulfur-containing amino acid, and is presumed to function as a natural antioxidant. The purpose of this study was to identify the nature […]

A comparison of the relative antioxidant potency of L-ergothioneine and idebenone.

A comparison of the relative antioxidant potency of L-ergothioneine and idebenone.AuthorsDong KK, Damaghi N, Kibitel J, et al. SourceJ Cosmet Dermatol 2007 Sep; 63 :183-8.Abstract BACKGROUND L-ergothioneine EGT is a stable antioxidant found in food plants as well as in animal tissue undergoing relatively high levels of oxidative stress. Idebenone is a stable analog of the antioxidant […]

Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system.

Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system. AuthorsMarkova NG, Karaman-Jurukovska N, Dong KK, et al. SourceFree Radic Biol Med 2009 Apr 15; 468 :1168-76. AbstractThe cellular defense system against harmful levels of reactive oxygen species consists of antioxidant enzymatic activities and small nonenzymatic molecules. L-ergothioneine has long […]